Newcastle disease virus vector vaccine strain for expressing F protein and G protein of C-type aMPV and application of Newcastle disease virus vector vaccine strain

The invention provides a Newcastle disease virus vector vaccine strain for expressing F protein and G protein of C-type aMPV and application of the Newcastle disease virus vector vaccine strain, and belongs to the technical field of veterinary vaccine strains. The NDV vector vaccine strain construct...

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Hauptverfasser: YU XIAOLU, HOU YUCHAO, SUN HUALU, LI YANG, CHU DIANFENG, DU YUANZHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a Newcastle disease virus vector vaccine strain for expressing F protein and G protein of C-type aMPV and application of the Newcastle disease virus vector vaccine strain, and belongs to the technical field of veterinary vaccine strains. The NDV vector vaccine strain constructed by the invention is used for preventing and controlling waterfowl C-type metapneumovirus, and solves the problem that no aMPV vaccine exists in the current market. The Newcastle disease virus serving as a host vector is subjected to gene modification, toxicity is attenuated, safety is good, pathogenicity to ducks is avoided, and the vector vaccine solves the safety risk that the toxicity of an aMPV attenuated live vaccine in the field is easy to return. The vector vaccine has a good immune effect, can induce an organism to generate humoral immunity, and can also induce the organism to generate cellular immunity and mucosal immunity, so that immune animals are protected in all directions, and a complete protectio