Enterobacter cloacae ZJUT16 and application thereof
The invention discloses an Enterobacter cloacae ZJUT16 and an application thereof. The Enterobacter cloacae ZJUT16 with the reduction reaction capability of a nitro compound (particularly m-nitroacetophenone) is obtained by screening from soil through a substrate enrichment culture strategy. The inv...
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| creator | WANG NANA LIU MEI HUANG CHANGSHUN DAI YANMEI OU ZHIMIN DENG LIXIA ZHANG QINGYU LUO LIANGLI WANG YANNI TAO ZIJUAN |
| description | The invention discloses an Enterobacter cloacae ZJUT16 and an application thereof. The Enterobacter cloacae ZJUT16 with the reduction reaction capability of a nitro compound (particularly m-nitroacetophenone) is obtained by screening from soil through a substrate enrichment culture strategy. The invention further discloses a preparation method of the Enterobacter cloacae ZJUT16 and an application of the Enterobacter cloacae ZJUT16. The nitroreductase EcNTR contained in the nitroreductase EcNTR can be used for reducing nitro compounds to prepare aromatic amines, and is especially used for converting m-nitroacetophenone to prepare an important intermediate m-aminoacetophenone in synthesis of phenylephrine drugs, antitumor drugs and sedative-hypnotic drugs.
本发明公开一种阴沟肠杆菌(Enterobacter cloacae)ZJUT16及其应用，通过底物富集培养策略从土壤中筛选获得一种具有硝基类化合物(特别是间硝基苯乙酮)还原反应能力的阴沟肠杆菌(Enterobacter cloacae)菌属菌株ZJUT16。其所含的硝基还原酶EcNTR可用于还原硝基类化合物制备芳香胺，特别用于转化间硝基苯乙酮制备苯肾上腺素药物、抗肿瘤药物及镇静催眠药合成中的重要中间体间氨基苯乙酮。 |
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本发明公开一种阴沟肠杆菌(Enterobacter cloacae)ZJUT16及其应用，通过底物富集培养策略从土壤中筛选获得一种具有硝基类化合物(特别是间硝基苯乙酮)还原反应能力的阴沟肠杆菌(Enterobacter cloacae)菌属菌株ZJUT16。其所含的硝基还原酶EcNTR可用于还原硝基类化合物制备芳香胺，特别用于转化间硝基苯乙酮制备苯肾上腺素药物、抗肿瘤药物及镇静催眠药合成中的重要中间体间氨基苯乙酮。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB2zStJLcpPSkwGUgrJOfmJyYmpClFeoSGGZgqJeSkKiQUFOZnJiSWZ-XkKJRmpRan5aTwMrGmJOcWpvFCam0HRzTXE2UM3tSA_PrW4IDE5NS-1JN7Zz9DQ3MTQ3MLM3NGYGDUAtXIr3A</recordid><startdate>20240119</startdate><enddate>20240119</enddate><creator>WANG NANA</creator><creator>LIU MEI</creator><creator>HUANG CHANGSHUN</creator><creator>DAI YANMEI</creator><creator>OU ZHIMIN</creator><creator>DENG LIXIA</creator><creator>ZHANG QINGYU</creator><creator>LUO LIANGLI</creator><creator>WANG YANNI</creator><creator>TAO ZIJUAN</creator><scope>EVB</scope></search><sort><creationdate>20240119</creationdate><title>Enterobacter cloacae ZJUT16 and application thereof</title><author>WANG NANA ; LIU MEI ; HUANG CHANGSHUN ; DAI YANMEI ; OU ZHIMIN ; DENG LIXIA ; ZHANG QINGYU ; LUO LIANGLI ; WANG YANNI ; TAO ZIJUAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117417867A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG NANA</creatorcontrib><creatorcontrib>LIU MEI</creatorcontrib><creatorcontrib>HUANG CHANGSHUN</creatorcontrib><creatorcontrib>DAI YANMEI</creatorcontrib><creatorcontrib>OU ZHIMIN</creatorcontrib><creatorcontrib>DENG LIXIA</creatorcontrib><creatorcontrib>ZHANG QINGYU</creatorcontrib><creatorcontrib>LUO LIANGLI</creatorcontrib><creatorcontrib>WANG YANNI</creatorcontrib><creatorcontrib>TAO ZIJUAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG NANA</au><au>LIU MEI</au><au>HUANG CHANGSHUN</au><au>DAI YANMEI</au><au>OU ZHIMIN</au><au>DENG LIXIA</au><au>ZHANG QINGYU</au><au>LUO LIANGLI</au><au>WANG YANNI</au><au>TAO ZIJUAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Enterobacter cloacae ZJUT16 and application thereof</title><date>2024-01-19</date><risdate>2024</risdate><abstract>The invention discloses an Enterobacter cloacae ZJUT16 and an application thereof. The Enterobacter cloacae ZJUT16 with the reduction reaction capability of a nitro compound (particularly m-nitroacetophenone) is obtained by screening from soil through a substrate enrichment culture strategy. The invention further discloses a preparation method of the Enterobacter cloacae ZJUT16 and an application of the Enterobacter cloacae ZJUT16. The nitroreductase EcNTR contained in the nitroreductase EcNTR can be used for reducing nitro compounds to prepare aromatic amines, and is especially used for converting m-nitroacetophenone to prepare an important intermediate m-aminoacetophenone in synthesis of phenylephrine drugs, antitumor drugs and sedative-hypnotic drugs.
本发明公开一种阴沟肠杆菌(Enterobacter cloacae)ZJUT16及其应用，通过底物富集培养策略从土壤中筛选获得一种具有硝基类化合物(特别是间硝基苯乙酮)还原反应能力的阴沟肠杆菌(Enterobacter cloacae)菌属菌株ZJUT16。其所含的硝基还原酶EcNTR可用于还原硝基类化合物制备芳香胺，特别用于转化间硝基苯乙酮制备苯肾上腺素药物、抗肿瘤药物及镇静催眠药合成中的重要中间体间氨基苯乙酮。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Enterobacter cloacae ZJUT16 and application thereof |
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