Cu-MOF/sulfonated hyaluronic acid hybrid coating on surface of cardiovascular and cerebrovascular stent material and preparation method of Cu-MOF/sulfonated hyaluronic acid hybrid coating

The invention discloses a Cu-MOF/sulfonated hyaluronic acid hybrid coating on the surface of a cardiovascular and cerebrovascular stent material and a preparation method of the Cu-MOF/sulfonated hyaluronic acid hybrid coating, and belongs to the field of cardiovascular and cerebrovascular stent mate...

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Hauptverfasser: GUAN SHAOKANG, QI LIUJIE, ZHANG ZHAOQI, SUN XIAOJING, LI JING'AN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a Cu-MOF/sulfonated hyaluronic acid hybrid coating on the surface of a cardiovascular and cerebrovascular stent material and a preparation method of the Cu-MOF/sulfonated hyaluronic acid hybrid coating, and belongs to the field of cardiovascular and cerebrovascular stent material surface treatment. The cardiovascular and cerebrovascular stent mainly solves the problem of endothelialization delay of the current cardiovascular and cerebrovascular stent, and has the function of promoting tissue repair of damaged blood vessel parts. The method mainly comprises the following three steps: preparing Cu-MOF powder, synthesizing a sulfonated hyaluronic acid material, and preparing the Cu-MOF/sulfonated hyaluronic acid hybrid coating. The Cu-MOF/sulfonated hyaluronic acid hybrid coating on the surface of the cardiovascular and cerebrovascular stent material obtained by the method is uniform, compact and high in adhesive force, and can remarkably promote proliferation and migration of endothelial