Acorus tatarinowii oil-tanshinone IIA O/W nanoemulsion and preparation method thereof

The tanshinone IIA is prepared into the rhizoma acori graminei oil-tanshinone IIA O/W nano-emulsion with uniform and stable particle size distribution by combining a modern dosage form O/W type nano-emulsion drug carrier on the basis of the medicinal characteristics of the main active ingredient rhizoma acori graminei oil of the traditional Chinese medicine rhizoma acori graminei. The nano-emulsion realizes brain delivery of the tanshinone IIA by virtue of self passive brain targeting and combination of the nano-emulsion and the rhizoma acori graminei oil, so that the brain targeting of the tanshinone IIA is remarkably improved, proliferation of brain glioma cells can be remarkably inhibited through an in-vitro blood brain barrier, and the nano-emulsion can be used as a nano-drug delivery system for treating the brain glioma. 本发明基于中药石菖蒲主要活性成分石菖蒲油"芳香开窍、引药上行"的药性特点，联合现代剂型O/W型纳米乳药物载体，将丹参酮IIA制备为粒径分布均匀、稳定的石菖蒲油-丹参酮IIA O/W纳米乳。该纳米乳以其自身被动脑靶向性，同时与石菖蒲油联合实现了对丹参酮IIA的脑部递送，显著提高了丹参酮IIA的脑靶向性，并可透过体外血脑屏障显著抑制脑胶质瘤细胞的增殖，可作为脑胶质瘤治疗的纳