Compositions and methods for assessing and treating t cell dysfunction

The present disclosure provides a modified immune cell or precursor thereof (e.g., a genetically edited modified T cell) comprising a modification in an endogenous locus encoding SOX and/or ID3. Methods for assessing and treating T cell dysfunction are also provided. 本公开提供了经修饰的免疫细胞或其前体(如，基因编辑的经修饰的T细...

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Hauptverfasser:	JUNE CARL H, KURAMITSU SHOKO, GOODE CHRISTOPHER R, YOUNG, RICHARD, MICHAEL, GOMEZ, MARCOS, A., A, BERGER, STEPHEN, L
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides a modified immune cell or precursor thereof (e.g., a genetically edited modified T cell) comprising a modification in an endogenous locus encoding SOX and/or ID3. Methods for assessing and treating T cell dysfunction are also provided. 本公开提供了经修饰的免疫细胞或其前体(如，基因编辑的经修饰的T细胞)，其包括编码SOX和/或ID3的内源性基因座中的修饰。还提供了用于评估和治疗T细胞功能障碍的方法。