Lopoxitinib for treatment of JAK-mediated conditions

Disclosed herein are JAK inhibitors with low systemic toxicity. In some aspects, the disclosure includes methods for treating disease states, disorders and conditions mediated by JAK, such as gastrointestinal system cancers, including colorectal cancer and familial adenomatous polyposis. 本文公开了具有低全身毒性的JAK抑制剂。在一些方面，本公开包括用于治疗由JAK介导的疾病状态、病症和病况的方法，所述疾病状态、病症和病况为诸如胃肠系统癌，包括结直肠癌和家族性腺瘤性息肉病。