Maytansine-antibody conjugates and methods of use thereof

Antibody-drug conjugates (ADCs) comprising an anti-TM4SF1 antibody, an antigen-binding fragment thereof, a linker, and a drug are described. The drug is a tubulin polymerization inhibitor. Methods of use of the ADC are also described. 描述了抗体-药物缀合物(ADC)，其包含抗TM4SF1抗体、其抗原结合片段、接头和药物。该药物是微管蛋白聚合抑制剂。还描述了ADC...

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Bibliographische Detailangaben
Hauptverfasser:	LUTZ ROBERT, JAMINET, PAUL, A, SHI SHOUQING, HUDLIKAR, MANISH, PRESTA LEONARD G, HA, EDWARD, H
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Antibody-drug conjugates (ADCs) comprising an anti-TM4SF1 antibody, an antigen-binding fragment thereof, a linker, and a drug are described. The drug is a tubulin polymerization inhibitor. Methods of use of the ADC are also described. 描述了抗体-药物缀合物(ADC)，其包含抗TM4SF1抗体、其抗原结合片段、接头和药物。该药物是微管蛋白聚合抑制剂。还描述了ADC的使用方法。