Sulfoxide imine compound with FGFR (Factor Growth Factor Receptor) inhibiting effect, pharmaceutical composition containing sulfoxide imine compound and application of sulfoxide imine compound

The invention provides a sulfoximine compound with an FGFR (Factor Growth Factor Receptor) inhibiting effect, a pharmaceutical composition containing the sulfoximine compound and application of the sulfoximine compound. The invention provides a sulfoximine compound which can be used as a fibroblast growth factor receptor (FGFR) inhibitor and is shown in a formula I, a tautomer, a stereoisomer, a hydrate, a solvate and pharmaceutically acceptable salt of the sulfoximine compound, a pharmaceutical composition containing the sulfoximine compound, and application of the sulfoximine compound in preparation of the pharmaceutical composition. Wherein R1, R2, R3, R4, R5, CyA, CyB, CyC and the like have the definitions given in the specification. # imgabs0 # 本发明提供了一种具有FGFR抑制作用的亚砜亚胺类化合物、包含其的药物组合物及其用途，具体地，本发明提供了一种可用作纤维母细胞生长因子受体(FGFR)抑制剂的如式I所示的亚砜亚胺类化合物、其互变异构体、立体异构体、水合物、溶剂化物、其药学上可接受的盐、包含该化合物的药物组合物，以及其在制备药物组合物中的应用。其中，R1、R2、R3、R4、R5、CyA、CyB、CyC等具有说明书中给出的定义。#imgabs0#