Anti-Sema3A antibodies and uses thereof

The present disclosure relates to isolated antibodies or antigen binding fragments thereof that bind to human Sema3A. The separated antibody or antigen binding fragment i) disclosed by the invention has a binding sequence of human Sema3A of SEQ ID NO: 600 and a dissociation constant (KD) of less than or equal to 50nM, less than or equal to 20nM, less than or equal to 10nM, less than or equal to 1nM or less than or equal to 0.1 nM; ii) cross-reacting with mouse, machin, rat, pig and/or dog Sema3A, in particular wherein the isolated antibody or antigen binding fragment thereof binds to mouse, machin, rat, pig and/or dog Sema3A with a dissociation constant (KD) of < = 50 nM, < = 20 nM, < = 10 nM, < = 1 nM or < = 0.1 nM; iii) human Sema3A with a binding sequence of SEQ ID NO: 600, wherein the binding activity of the human Sema3A is greater than or equal to 60%, greater than or equal to 70%, greater than or equal to 80% or greater than or equal to 90% as determined by surface plasmon resonance (SPR); iv) the activ