Method for detecting influence of diet on oral absorption of rosuvastatin based on PBPK model
The invention relates to a method for detecting influence of diet on oral absorption of rosuvastatin based on a PBPK model. The method comprises the following steps: collecting basic attribute parameters and clinical pharmacokinetic parameters of a rosuvastatin drug; establishing a rosuvastatin fast...
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| creator | YU YUNLI SUN YEWEN |
| description | The invention relates to a method for detecting influence of diet on oral absorption of rosuvastatin based on a PBPK model. The method comprises the following steps: collecting basic attribute parameters and clinical pharmacokinetic parameters of a rosuvastatin drug; establishing a rosuvastatin fasting and postprandial PBPK model; performing fitting verification on the model by using actually measured blood concentration data of oral administration of the healthy person on an empty stomach and after meal; and analyzing and exploring the influence of each factor on postprandial absorption of rosuvastatin by adopting parameter sensitivity. The PBPK model is helpful for exploring the possible mechanism that food causes reduced absorption of rosuvastatin, provides meaningful guidance for individualized treatment of the medicines, and provides reasonable diet suggestions for patients with hyperlipidemia to take BCSIII statins.
本发明涉及一种基于PBPK模型检测饮食对瑞舒伐他汀口服吸收影响的方法，步骤包括：收集瑞舒伐他汀药物基本属性参数及临床药代动力学参数；建立瑞舒伐他汀空腹及餐后PBPK模型；用实测 |
| format | Patent |
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本发明涉及一种基于PBPK模型检测饮食对瑞舒伐他汀口服吸收影响的方法，步骤包括：收集瑞舒伐他汀药物基本属性参数及临床药代动力学参数；建立瑞舒伐他汀空腹及餐后PBPK模型；用实测</description><language>chi ; eng</language><subject>HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA ; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS ; PHYSICS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240109&DB=EPODOC&CC=CN&NR=117373609A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240109&DB=EPODOC&CC=CN&NR=117373609A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YU YUNLI</creatorcontrib><creatorcontrib>SUN YEWEN</creatorcontrib><title>Method for detecting influence of diet on oral absorption of rosuvastatin based on PBPK model</title><description>The invention relates to a method for detecting influence of diet on oral absorption of rosuvastatin based on a PBPK model. The method comprises the following steps: collecting basic attribute parameters and clinical pharmacokinetic parameters of a rosuvastatin drug; establishing a rosuvastatin fasting and postprandial PBPK model; performing fitting verification on the model by using actually measured blood concentration data of oral administration of the healthy person on an empty stomach and after meal; and analyzing and exploring the influence of each factor on postprandial absorption of rosuvastatin by adopting parameter sensitivity. The PBPK model is helpful for exploring the possible mechanism that food causes reduced absorption of rosuvastatin, provides meaningful guidance for individualized treatment of the medicines, and provides reasonable diet suggestions for patients with hyperlipidemia to take BCSIII statins.
本发明涉及一种基于PBPK模型检测饮食对瑞舒伐他汀口服吸收影响的方法，步骤包括：收集瑞舒伐他汀药物基本属性参数及临床药代动力学参数；建立瑞舒伐他汀空腹及餐后PBPK模型；用实测</description><subject>HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA</subject><subject>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</subject><subject>PHYSICS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi8EKwjAQBXvxIOo_rB8gWAoWj1oUQZQevErZNi8aiNmSbP1-LfgBnoaBmWl2v0CfYshKJANFpy48yAXrB4QOJJaMg5IEksieuE0Se3WjW4qShjcn5e9FLSeYMaz39ZleYuDn2cSyT1j8OMuWx8OtOq3QS4PUc4cAbaprnpdFWWzW213xT_MBrmo7jw</recordid><startdate>20240109</startdate><enddate>20240109</enddate><creator>YU YUNLI</creator><creator>SUN YEWEN</creator><scope>EVB</scope></search><sort><creationdate>20240109</creationdate><title>Method for detecting influence of diet on oral absorption of rosuvastatin based on PBPK model</title><author>YU YUNLI ; SUN YEWEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117373609A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA</topic><topic>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</topic><topic>PHYSICS</topic><toplevel>online_resources</toplevel><creatorcontrib>YU YUNLI</creatorcontrib><creatorcontrib>SUN YEWEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YU YUNLI</au><au>SUN YEWEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for detecting influence of diet on oral absorption of rosuvastatin based on PBPK model</title><date>2024-01-09</date><risdate>2024</risdate><abstract>The invention relates to a method for detecting influence of diet on oral absorption of rosuvastatin based on a PBPK model. The method comprises the following steps: collecting basic attribute parameters and clinical pharmacokinetic parameters of a rosuvastatin drug; establishing a rosuvastatin fasting and postprandial PBPK model; performing fitting verification on the model by using actually measured blood concentration data of oral administration of the healthy person on an empty stomach and after meal; and analyzing and exploring the influence of each factor on postprandial absorption of rosuvastatin by adopting parameter sensitivity. The PBPK model is helpful for exploring the possible mechanism that food causes reduced absorption of rosuvastatin, provides meaningful guidance for individualized treatment of the medicines, and provides reasonable diet suggestions for patients with hyperlipidemia to take BCSIII statins.
本发明涉及一种基于PBPK模型检测饮食对瑞舒伐他汀口服吸收影响的方法，步骤包括：收集瑞舒伐他汀药物基本属性参数及临床药代动力学参数；建立瑞舒伐他汀空腹及餐后PBPK模型；用实测</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS PHYSICS |
| title | Method for detecting influence of diet on oral absorption of rosuvastatin based on PBPK model |
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