Chiral MOFs material and application thereof in resolution of chiral drug amlodipine
The invention discloses a chiral MOFs material which is prepared by the following steps: dissolving 2-aminoterephthalic acid in N, N-dimethylformamide to obtain an initial solution; stirring for 3-4 hours, keeping the temperature at 110 DEG C, adding aluminum chloride hexahydrate for 5-8 times withi...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a chiral MOFs material which is prepared by the following steps: dissolving 2-aminoterephthalic acid in N, N-dimethylformamide to obtain an initial solution; stirring for 3-4 hours, keeping the temperature at 110 DEG C, adding aluminum chloride hexahydrate for 5-8 times within 75-120 minutes, continuously stirring for 3-4 hours, stopping stirring, keeping the temperature in a static state, and reacting for 15-20 hours; after cooling, carrying out solid-liquid separation, washing and drying, activating the obtained powder in boiling ethanol, and then carrying out vacuum drying to obtain MIL-101-NH2 (Al); the preparation method comprises the following steps: mixing chiral amino acid, a coupling agent and activated MIL-101-NH2 (Al) in an MES buffer solution, and carrying out reflux stirring reaction at room temperature for 110-125 hours; carrying out solid-liquid separation, washing and drying to obtain a chiral MOFs material; the chiral amino acid is one of L-glutamic acid and L-tryptoph |
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