Composite hydrogel based on reducing sugar and dopamine and preparation method thereof

The invention discloses composite hydrogel based on reducing sugar and dopamine and a preparation method of the composite hydrogel. Firstly, glucose/maltose and acrylic anhydride are subjected to an esterification reaction to obtain corresponding ester, and then through a Michael addition reaction, the obtained ester, dopamine hydrochloride and polyethylene glycol diacrylate are synthesized into the acrylate-terminated hyperbranched polymer under the condition that the ratio of double bonds to active hydrogen is 1.8: 1. The composite material hydrogel is prepared by taking glucose/maltose and dopamine as raw materials, the preparation method of the hydrogel is simple, the raw materials are easy to obtain, and the hydrogel has the advantages of good adhesion performance, biocompatibility, low cytotoxicity and the like. 本发明公开一种基于还原糖和多巴胺的复合水凝胶及其制备方法。首先将葡萄糖/麦芽糖和丙烯酸酐通过酯化反应得到相应的酯，然后通过迈克尔加成反应，以双键与活性氢的比例为1.8:1的条件，将得到的酯与盐酸多巴胺、聚乙二醇二丙烯酸酯合成丙烯酸酯端基超支化聚合物。本发明以葡萄糖/麦芽糖和多巴胺为原料制备的一种复合材料水凝胶，该水凝胶制备方法简单，原料容易获得，具有良好的黏附性能、生物相容性和细胞毒性