Recombinant adeno-associated virus for expressing ENO1 human-mouse chimeric antibody and preparation method of recombinant adeno-associated virus

The invention is applicable to the technical field of biological medicines, and provides a preparation method of a recombinant adeno-associated virus for expressing an ENO1 human-mouse chimeric antibody, which comprises the following steps: constructing and identifying rAAV-ENO1-ximab plasmid; and p...

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Hauptverfasser:	DAI PENGYU, ZHANG TINGTING, MA XINYUN, CHO WON-WOOK, ZHU BINGDONG, LIU HUILING, YANG RUI, ZHOU JUANHONG, PEI YAPING, YANG NAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention is applicable to the technical field of biological medicines, and provides a preparation method of a recombinant adeno-associated virus for expressing an ENO1 human-mouse chimeric antibody, which comprises the following steps: constructing and identifying rAAV-ENO1-ximab plasmid; and preparing the rAAV-ENO1-ximab recombinant adeno-associated virus. The invention also provides the rAAV-ENO1-ximab recombinant adeno-associated virus prepared by the preparation method of the recombinant adeno-associated virus for expressing the ENO1 human-mouse chimeric antibody, and the rAAV-ENO1-ximab recombinant adeno-associated virus is obtained by the preparation method of the recombinant adeno-associated virus. The invention also provides an application of the rAAV-ENO1-ximab recombinant adeno-associated virus in preparation of drugs for inhibiting proliferation, migration or glycolysis of cervical cancer cells. The rAAV-ENO1-ximmAb recombinant adeno-associated virus prepared by the invention has an obvious in