Synthesis method of 2-trideuterium methyl-1-(pyridine-2-yl) indole compound

The invention belongs to the field of chemical synthesis, and particularly relates to a synthetic method of a 2-trideuterium methyl-1-(pyridine-2-yl) indole compound. A 1-(pyridine-2-yl) indole compound is used as a reaction substrate, DMSO-d6 is used as a trideuterium methylation reagent and solvent, Cu (OAc) 2 is used as a catalyst, tert-butyl peroxybenzoate is used as an oxidizing agent, 1, 3-bis (diphenylphosphine) propane is used as a ligand, a trideuterium methylation reaction is carried out on the C2 site of the 1-(pyridine-2-yl) indole compound, and the 1-(pyridine-2-yl) indole compound is obtained. And the corresponding 2-trideuterium methyl-1-(pyridine-2-yl) indole compound is prepared by using a one-pot method. The invention solves the problems of limited raw material source and high safety risk in the synthesis process in the prior art, and the synthesis method is simple and convenient to operate, safe and reliable, and has broad spectrum. 本发明属于化学合成领域，具体涉及一种2-三氘甲基-1-(吡啶-2-基)吲哚化合物的合成方法。本发明使用1-(吡啶-2