Novel injectable temperature-sensitive in-situ curing hydrogel and preparation method thereof

The invention relates to a preparation method of novel injectable temperature-sensitive in-situ curing hydrogel, which specifically comprises the following steps: adding triple distilled water and nano silicate bioactive glass powder into a beaker, mixing to form turbid liquid, continuing to add kon...

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Bibliographische Detailangaben
Hauptverfasser: XING YANG, ZHANG MEI, WANG YITONG, JIANG HONGWEI, LI GUANGDA, LIU JIANGTAO, MA ZEXU, LI HUIYAO, DAI YUELING, MA YUJIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a preparation method of novel injectable temperature-sensitive in-situ curing hydrogel, which specifically comprises the following steps: adding triple distilled water and nano silicate bioactive glass powder into a beaker, mixing to form turbid liquid, continuing to add konjac glucomannan, uniformly mixing to form suspended mixed colloid A, adding xanthan gum into the suspended mixed colloid A, and uniformly mixing to obtain the injectable temperature-sensitive in-situ curing hydrogel. The preparation method comprises the following steps: uniformly mixing the components to form a suspension mixed colloid B, transferring the suspension mixed colloid B into an injector for packaging, standing and heating the packaged material in a water bath at 55-60 DEG C for 25-35 minutes, gelatinizing the material, and cooling at room temperature to obtain the injectable temperature-sensitive and in-situ cured hydrogel. The hydrogel prepared by the invention does not need to be prepared and used on