Triptolide-loaded photo-thermal driving motor microneedle for treating rheumatoid arthritis and preparation method of triptolide-loaded photo-thermal driving motor microneedle

The invention provides a triptolide-loaded photo-thermal driving motor microneedle for treating rheumatoid arthritis, which is used for improving the effectiveness of TG on RA clinical treatment and the compliance of a patient and improving the transdermal local tissue drug delivery efficiency of transdermal drug delivery at the same time. Meanwhile, the invention provides a method for preparing the novel skin administration preparation. Comprising the following components: 300 to 500 parts of a silicon nano bottle modified by folic acid PEG (polyethylene glycol), 15 to 20 parts of triptolide, 5 to 30 parts of perfluorohexane, 5 to 10 parts of indocyanine green, 100 to 200 parts of tetradecanol and 1 to 10 parts of pure water. 本发明提供一种治疗类风湿性关节炎的载雷公藤甲素光热驱动马达微针，以提高TG对RA临床治疗的有效性与患者顺应性，同时提高经皮给药皮下局部组织药物递送效率；同时提供制备上述新型皮肤给药制剂的方法；包括如下内容：一种治疗类风湿性关节炎的载雷公藤甲素光热驱动马达微针，包括以下组分：叶酸PEG修饰的硅纳米瓶300-500份，雷公藤甲素15-20份，全氟己烷5-30份，吲哚菁绿5-10份，十四醇100-200份，纯水1-10份。