SaRNA for activating CDH13 gene expression and application thereof

The invention provides saRNA (Ribonucleic Acid) for activating CDH13 gene expression and an application of the saRNA. According to the invention, four cell strains are selected from a leukemia cell line, and saRNAs sequences capable of effectively up-regulating CDH13-mRNA and protein expression are screened on the four cells. In the invention, after the CDH13saRNAs are transfected, the up-regulation multiple of CDH13mRNA (messenger ribonucleic acid) is 1.53 to 2.37 times. The difference of induction effects may be related to the complexity of target gene promoter elements, cell types and transfection reagents. After the expression of CDH13 is up-regulated successfully, the relative activity and cell proliferation ability of K562, KCL22, KU812 and NB4 cells can be inhibited. Experimental results prove that after overexpression of the gene, proliferation of cancer cells can be inhibited, so that the progress of diseases is hindered. 本发明提供了一种激活CDH13基因表达的saRNA及其应用。本发明在白血病细胞系中选取了四种细胞株，并在这四种细胞上筛选出有效上调CDH13-mRNA和蛋白表