Method for reversing senescence brain function decline

The invention relates to the technical field of medicine, and provides a composition for treating brain function decline in the aging process and application of the composition, and the composition comprises a GLP-1R agonist and is used for treating aging-related brain dysfunction. In some embodiments, the GLP-1R agonist is exenatide, liraglutide, lisinide, albiglutide, dulatide, semeglutide, tasiglutide, PF-06882961, OWL-833, TTP-273, or any other molecule that activates GLP-1R. The invention also relates to a method for preparing the GLP-1R agonist. 本发明涉及医药技术领域，提供了一种治疗衰老过程中脑功能衰退的组合物及其应用，所述组合物包括GLP-1R激动剂，用于治疗所述衰老相关脑功能障碍。所述GLP-1R激动剂是艾塞那肽、利拉鲁肽、利司那肽、阿必鲁肽、度拉糖肽、司美格鲁肽、他司鲁肽、PF-06882961、OWL-833、TTP-273或激活GLP-1R的任何其他分子。