Engineered natural killer cells and uses thereof

The present invention provides engineered natural killer cells modified to express a chimeric antigen receptor (CAR). The cells optionally contain other modifications that improve tumor-specific cytotoxicity and homing to the tumor site. Methods of treating cancer patients using engineered natural k...

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Bibliographische Detailangaben
1. Verfasser:	O 'DWYER MICHAEL EAMON PETER
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides engineered natural killer cells modified to express a chimeric antigen receptor (CAR). The cells optionally contain other modifications that improve tumor-specific cytotoxicity and homing to the tumor site. Methods of treating cancer patients using engineered natural killer cells are also contemplated. 本发明提供了经过修饰以表达嵌合抗原受体(CAR)的工程化天然杀伤细胞。该细胞任选地含有改善肿瘤特异性细胞毒性和归巢至肿瘤部位的其他修饰。本发明还考虑了使用工程化天然杀伤细胞治疗癌症患者的方法。