Medical coating as well as preparation method and application thereof

The invention discloses a medical coating as well as a preparation method and application thereof, the medical coating comprises a modified anionic polymer hydrogel layer and a modified cationic polymer hydrogel layer which are alternately stacked, and the modified anionic polymer hydrogel layer comprises an anionic polymer grafted with a catechol group; the modified positive charge polymer layer comprises a cationic polymer grafted with a catechol group. The medical coating is modified based on natural macromolecules, and the nanoscale coating has excellent composite functions of super-strong adhesiveness, hydrophilic lubricity, low damage, safety, reliability, good biocompatibility and blood compatibility (good hemolysis experiment effect), bacteria prevention, protein adhesion and the like. The medical coating is simple in preparation method and wide in application range. 本发明公开了一种医用涂层及其制备方法和应用，该医用涂层包括交替层叠的改性阴离子聚合物水凝胶层和改性阳离子聚合物水凝胶层，所述改性阴离子聚合物水凝胶层包括接枝邻苯二酚基团的阴离子聚合物；所述改性正电荷聚合物层包括接枝邻苯二酚基团的阳离子聚合物。本发明医用涂层基于天然大分子改