Artificial anterior lamella cornea composite material and preparation method thereof

The invention discloses an artificial anterior lamella cornea composite material and a preparation method thereof. The preparation method of the artificial anterior lamellar cornea composite material comprises the following steps: (1) adding silk fibroin into a solvent, then adding salt, and uniform...

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Hauptverfasser: CHEN YUQING, ZHONG XINGXIA, GUAN XIPENG, CAO ZHAOZHAO, WEI XIAOHUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an artificial anterior lamella cornea composite material and a preparation method thereof. The preparation method of the artificial anterior lamellar cornea composite material comprises the following steps: (1) adding silk fibroin into a solvent, then adding salt, and uniformly mixing to obtain slurry; (2) pouring the slurry into an artificial cornea anterior lamella mold for compression molding, then putting the mold into alcohol for soaking, taking out the mold after soaking is finished, and separating a membrane material from the mold to obtain a silk fibroin membrane material; and (3) putting the silk fibroin membrane material into a buffer solution, then adding the acellular matrix hydrogel and carbodiimide EDC for cross-linking reaction, after the cross-linking reaction is finished, taking out the membrane material, and cleaning to obtain the artificial anterior lamellar cornea composite material. The artificial anterior lamellar cornea composite material has relatively large sut