N-substituted benzy or phenyl aromatic amide copmound and its use

N-(3，5-双-二取代氨甲基-4-羟基)苄基芳香磺酰胺和N-(3，5-双-二取代氨甲基-4-羟基)苯基芳香磺酰胺化合物在动物试验中有预防和治疗心律失常的作用。这些化合物由相应的带有各种取代基的芳香磺酰氯与对羟苄胺、对氨基苯酚等缩合生成相应的芳香磺酰胺，再与甲醛和仲胺通过曼尼希反应制得相应的二胺。也可由芳香磺酰氯与4-氨基-2，6-双-二取代氨甲基苯酚直接反应制得二胺。二胺化合物再与各种酸生成盐。 N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)benzyl aromatic sulfonamides and N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)phenyl aromatic sulfonamides compounds in accordance with the animal test, are active in the prevention and the treatment of cardiac arrhythmia. These compounds are prepared as corresponding diamines by the condensation of optionally substituted aromatic sulfochlorides with p-hydroxybenzylamine, p-aminophenol, or the like, which followed by the Mannich reaction of the resulted corresponding aromatic sulfamides with formaldehyde and secondary amines; or directly obtained by the reaction of the aromatic sulfamides with 4-amino-2,6-bis-disubstituted aminomethylphenol. Subsequently, the diamines are reacted with various acids to provide their salts.