Antigen binding molecules targeting CD20 and CD22 for use in proliferative diseases

The present invention provides antigen binding molecules targeting CD20 and CD22 characterized by comprising a first domain and a second domain that bind to CD20 and CD22, respectively, a third domain that binds to extracellular epitopes of human and macaque CD3 epsilon chains, and optionally a fourth domain that is of Fc mode. In addition, the invention provides a polynucleotide encoding the antigen-binding molecule, a vector comprising such a polynucleotide, a host cell expressing the antigen-binding molecule, and a pharmaceutical composition comprising the antigen-binding molecule. 本发明提供了靶向CD20和CD22的抗原结合分子，其特征在于包含分别与CD20和CD22结合的第一结构域和第二结构域、与人和猕猴CD3ε链的细胞外表位结合的第三结构域以及可选地第四结构域，该第四结构域是Fc模式。此外，本发明提供了编码该抗原结合分子的多核苷酸、包含这种多核苷酸的载体、表达该抗原结合分子的宿主细胞、以及包含该抗原结合分子的药物组合物。