Compositions and methods for inducing ESR1, PI3K, HER2 and HER3 immune responses

The present disclosure relates to the field of molecular virology and in particular to nucleic acid molecules encoding a modified equine encephalitis virus viral genome or a self-replicating RNA (srRNA) construct, pharmaceutical compositions containing said nucleic acid molecules and the use of such nucleic acid molecules and compositions for producing a desired product in a cell culture or in vivo. Also provided are methods for eliciting an immune response in a subject in need thereof and methods for preventing and/or treating cancer. 本公开文本涉及分子病毒学领域，并且具体地涉及编码经修饰的马脑炎病毒病毒基因组或自复制RNA(srRNA)构建体的核酸分子、含有所述核酸分子的药物组合物以及此类核酸分子和组合物用于在细胞培养物或活体中产生所需产物的用途。还提供了用于在有需要的受试者中引发免疫应答的方法以及用于预防和/或治疗癌症的方法。