RNAi inhibitor for inhibiting expression of angiotensinogen gene and application of RNAi inhibitor

The invention relates to siRNA (small interfering Ribonucleic Acid) for inhibiting the expression of angiotensinogen (AGT), which comprises a positive-sense strand and an antisense strand, and the sequence of the positive-sense strand is shown as AGCCACAGAGUCUACCCAAU; and the sequence of the antisense strand is as shown in AUUGGGUAGACUCUGUGGGCUCU. The invention also provides a modified siRNA (small interfering Ribonucleic Acid) used for inhibiting the expression of angiotensin (AGT), the sequence of the positive-sense strand is shown as mAsmGsmCmCmCmAfCmAmGfGmUfCmCmCmAmAmU, the sequence of the antisense strand is shown as The siRNA and the proper modification sequence thereof disclosed by the invention have good in-vitro and in-vivo biological activity, and are expected to be clinically applied to hypertension treatment. 本发明涉及一种用于抑制血管紧张素原(AGT)表达的siRNA，包括正义链及反义链，所述正义链序列如AGCCCACAGAGUCUACCCAAU所示；所述反义链序列如AUUGGGUAGACUCUGUGGGCUCU所示。还提供了一种经过了修饰的、用于抑制血管紧张素原(AGT)表达的siRNA，所述正义链序列如mAsmGsmCmCmCmAfCmAdGfAfGmUfCmUmAmCmCmCm