Composition

The present invention provides a solid pharmaceutical composition for delivery of a pharmaceutically active binding polypeptide to a region of the intestinal tract by oral administration comprising a compressed core wherein the compressed core comprises a pharmaceutically active binding polypeptide,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FRODSHAM MICHAEL, WHALE GARY, WAHLICH JOHN, CUBITT MARION, ROBERTS KEVIN, MAGGIORE LUANA, CROWE SCOTT, CARLTON TIM, WEST MICHAEL
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The present invention provides a solid pharmaceutical composition for delivery of a pharmaceutically active binding polypeptide to a region of the intestinal tract by oral administration comprising a compressed core wherein the compressed core comprises a pharmaceutically active binding polypeptide, and wherein the compressed core is coated with a pH-sensitive enteric coating. 本发明提供了用于通过口服施用将药物活性结合多肽递送至肠道区域的固体药物组合物,其包含压制芯,其中所述压制芯包含药物活性结合多肽,且其中压制芯用pH敏感型肠溶包衣进行了包衣。