HPV vaccine production

The present invention describes a method for preparing an HPV vaccine composition by, for example, (i) adsorbing one or more HPV antigens on a metal salt, and then (ii) adding an unadsorbed glycolipid-based TLR4 ligand to the mixture obtained in (I). The resulting HPV vaccine compositions and uses thereof are also described. 本发明描述了用于通过以下制备HPV疫苗组合物的方法：例如(i)将一种或多种HPV抗原吸附在金属盐上，然后(ii)向(I)中获得的混合物中添加未吸附的基于糖脂的TLR4配体。还描述了所得的HPV疫苗组合物及其用途。