Respiratory syncytial virus replication inhibitors

本发明涉及作为呼吸道合胞病毒复制抑制剂的式(I)化合物、它们的前药、N-氧化物、加成盐、季铵、金属络合物或立体化学异构形式，它们的制备、包含它们的组合物和它们的作为药物的用途，∴其中Q为下式基团：∴-a#+[1]＝a#+[2]-a#+[3]＝a#+[4]-、Alk、Y#+[1]、X#+[1]、X#+[2]、t、u、v、G、R#+[1]、R#+[2]和R#+[4]如说明书中所述。 The present invention concerns compounds of formula prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a =a -a =a - represents a radical of formula -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; - CH=CH-CH=N-; wherein each hydrogen atom may optionally be substituted; Q is a radical of formula wherein Alk is C1-6alkanediyl; Y is a bivalent radical of formula -NR - or -CH(NR R )-; X is NR , S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR R ), CH2-NR or NR -CH2; X is a direct bond, CH2, C(=O), NR , C1-4alkyl-NR , NR -C1-4alkyl; v is 2 or 3; and whereby each hydrogen in Alk and in (b-6), (b-7) and (b-8), may optionally be replaced by R ; provided that when R is hydroxy or C1-6alkyloxy, then R can not replace a hydrogen atom in the alpha position relative to a nitrogen atom; G is a direct bond or optionally substituted C1-10alkanediyl; R is an optionally substituted bicyclic heterocycle; R is hydrogen, formyl, C1-6 alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R )2 and optionally with another substituent; R is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy; R is hydrogen, C1-6alkyl or arylC1-6alkyl; R , R , R and R are hydrogen or C1-6alkyl; or R and R , or R and R taken together from a bivalent radical of formula -(CH2)s- wherein s is 4 or 5; R is hydrogen, C1-4alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.