Production method of bisamide compound
The invention provides a bisamide compound production method, which comprises: A) carrying out an acylation reaction on substituted pyrazole formic acid and an acylating chlorination reagent in a first dynamic tubular reactor to obtain substituted pyrazole formyl chloride; and B) carrying out conden...
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| creator | XIAO SHUHUAN WANG WENCHAO WANG MINGLI ZOU SHANSHAN CHE ZUXIAO QIN ZHAOBIN LIU CHANGXIN |
| description | The invention provides a bisamide compound production method, which comprises: A) carrying out an acylation reaction on substituted pyrazole formic acid and an acylating chlorination reagent in a first dynamic tubular reactor to obtain substituted pyrazole formyl chloride; and B) carrying out condensation reaction on the substituted pyrazole formyl chloride obtained in the step A) and anthranilamide in a second dynamic tubular reactor to obtain the bisamide compound. According to the invention, the use of dehydration coupling agents such as methanesulfonyl chloride is avoided, so that the problems of difficult treatment of three wastes and low cost caused by the use of methanesulfonyl chloride are avoided. The continuous reaction is realized, the usage amount of the acylating chlorination reagent in the acylation reaction stage is reduced, the side reaction of the acylating chlorination reagent and anthranilamide is avoided, the obtained acylation reaction liquid can be directly introduced into a condensation |
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According to the invention, the use of dehydration coupling agents such as methanesulfonyl chloride is avoided, so that the problems of difficult treatment of three wastes and low cost caused by the use of methanesulfonyl chloride are avoided. The continuous reaction is realized, the usage amount of the acylating chlorination reagent in the acylation reaction stage is reduced, the side reaction of the acylating chlorination reagent and anthranilamide is avoided, the obtained acylation reaction liquid can be directly introduced into a condensation</description><language>chi ; eng</language><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231208&DB=EPODOC&CC=CN&NR=117186059A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231208&DB=EPODOC&CC=CN&NR=117186059A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XIAO SHUHUAN</creatorcontrib><creatorcontrib>WANG WENCHAO</creatorcontrib><creatorcontrib>WANG MINGLI</creatorcontrib><creatorcontrib>ZOU SHANSHAN</creatorcontrib><creatorcontrib>CHE ZUXIAO</creatorcontrib><creatorcontrib>QIN ZHAOBIN</creatorcontrib><creatorcontrib>LIU CHANGXIN</creatorcontrib><title>Production method of bisamide compound</title><description>The invention provides a bisamide compound production method, which comprises: A) carrying out an acylation reaction on substituted pyrazole formic acid and an acylating chlorination reagent in a first dynamic tubular reactor to obtain substituted pyrazole formyl chloride; and B) carrying out condensation reaction on the substituted pyrazole formyl chloride obtained in the step A) and anthranilamide in a second dynamic tubular reactor to obtain the bisamide compound. According to the invention, the use of dehydration coupling agents such as methanesulfonyl chloride is avoided, so that the problems of difficult treatment of three wastes and low cost caused by the use of methanesulfonyl chloride are avoided. 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According to the invention, the use of dehydration coupling agents such as methanesulfonyl chloride is avoided, so that the problems of difficult treatment of three wastes and low cost caused by the use of methanesulfonyl chloride are avoided. The continuous reaction is realized, the usage amount of the acylating chlorination reagent in the acylation reaction stage is reduced, the side reaction of the acylating chlorination reagent and anthranilamide is avoided, the obtained acylation reaction liquid can be directly introduced into a condensation</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | Production method of bisamide compound |
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