Production method of bisamide compound

The invention provides a bisamide compound production method, which comprises: A) carrying out an acylation reaction on substituted pyrazole formic acid and an acylating chlorination reagent in a first dynamic tubular reactor to obtain substituted pyrazole formyl chloride; and B) carrying out conden...

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Bibliographische Detailangaben
Hauptverfasser: XIAO SHUHUAN, WANG WENCHAO, WANG MINGLI, ZOU SHANSHAN, CHE ZUXIAO, QIN ZHAOBIN, LIU CHANGXIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a bisamide compound production method, which comprises: A) carrying out an acylation reaction on substituted pyrazole formic acid and an acylating chlorination reagent in a first dynamic tubular reactor to obtain substituted pyrazole formyl chloride; and B) carrying out condensation reaction on the substituted pyrazole formyl chloride obtained in the step A) and anthranilamide in a second dynamic tubular reactor to obtain the bisamide compound. According to the invention, the use of dehydration coupling agents such as methanesulfonyl chloride is avoided, so that the problems of difficult treatment of three wastes and low cost caused by the use of methanesulfonyl chloride are avoided. The continuous reaction is realized, the usage amount of the acylating chlorination reagent in the acylation reaction stage is reduced, the side reaction of the acylating chlorination reagent and anthranilamide is avoided, the obtained acylation reaction liquid can be directly introduced into a condensation