Benzofuran compound in eupatorium chinense and application of benzofuran compound in treatment of depression

The invention discloses a benzofuran compound in eupatorium chinense and application of the benzofuran compound in treatment of depression. The benzofuran compound is obtained by being separated from a traditional Chinese medicinal material eupatorium chinense, and is named as 10R-2-(10-methyl-10, 1...

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Hauptverfasser: HUANG NIANYU, ZOU KUN, QIN QIANGSU, LIU CHENGXIONG, HE HAIBO, YANG HUISHU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a benzofuran compound in eupatorium chinense and application of the benzofuran compound in treatment of depression. The benzofuran compound is obtained by being separated from a traditional Chinese medicinal material eupatorium chinense, and is named as 10R-2-(10-methyl-10, 11-dihydroxy)-5-acetyl-6-hydroxybenzofuran. According to the preparation method of the benzofuran compound, the benzofuran compound is obtained through the steps of solvent extraction, activated carbon decoloration, macroporous adsorption column chromatography and crystallization separation by taking the root of traditional Chinese medicine eupatorium chinense as a raw material, and the separation method is simple, effective, high in purity and suitable for industrial production. Animal experiments show that the benzofuran compound is subjected to behavioral data analysis such as mouse sweet water preference degree, tail suspension test, elevated cross maze test, forced swimming test and open field experiment. The b