Novel method for synthesizing key intermediate of cebrumex

The invention provides a Hibomib intermediate and a preparation method thereof. According to the invention, improvement and optimization are carried out on the basis of the prior art, and the improvement of a carboxylation process and a carboxyl reduction process is involved, so that the total yield of the intermediate (Z)-5-(4-fluorophenyl)-6-hydroxy-hex-4-olefine acid is increased by 75.3%, and the total yield of the cebrumex is also increased by 75.3%. 本发明提供海博麦布中间体及其制备方法。本发明在现有技术的基础上进行改良优化，其中涉及羧基化工艺和羧基还原工艺的改进，使得中间体(Z)-5-(4-氟苯基)-6-羟基-己-4-烯酸总收率提高75.3％，海博麦布总收率也提升了75.3％。