AHA1 inhibitor with anti-multiple myeloma activity as well as preparation method and application of AHA1 inhibitor

The invention relates to an AHA1 inhibitor with an anti-multiple myeloma effect and a preparation method and application thereof, in particular to a compound shown as a formula (I) or a stereoisomer, a geometric isomer, a tautomer, a pharmaceutically acceptable salt or a prodrug thereof. The AHA1 small-molecule inhibitor synthesized by the invention can influence related signal channels to directly inhibit proliferation of multiple myeloma (MM) cells, and also can influence interaction of exosomes, tumor cells and a microenvironment so as to inhibit malignant proliferation of the MM. # imgabs0 # 本发明涉及一种具有抗多发性骨髓瘤作用的AHA1抑制剂及其制备方法和应用，具体涉及式(I)化合物或其立体异构体、几何异构体、互变异构体、药学上可接受的盐或前药。本发明合成的AHA1小分子抑制剂能影响相关信号通路而直接抑制多发性骨髓瘤(MM)细胞的增殖，同时还能够影响外泌体与肿瘤细胞及微环境的相互作用，进而抑制MM恶性增殖。#imgabs0#