Preparation method of 2-trifluoromethoxybenzenesulfonamide

Preparation method of 2-trifluoromethoxybenzenesulfonamide

The invention discloses a preparation method of 2-trifluoromethoxybenzenesulfonamide, and belongs to the technical field of medical intermediates. O-amino trifluoromethoxybenzene is used as a starting raw material, 2-trifluoromethoxybenzene sulfonyl chloride is synthesized through diazotization, chl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: JIANG DIANBAO, ZHOU XIN, ZAN SHUJIN
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator JIANG DIANBAO
ZHOU XIN
ZAN SHUJIN
description The invention discloses a preparation method of 2-trifluoromethoxybenzenesulfonamide, and belongs to the technical field of medical intermediates. O-amino trifluoromethoxybenzene is used as a starting raw material, 2-trifluoromethoxybenzene sulfonyl chloride is synthesized through diazotization, chlorosulfonation and oxidation, and then the 2-trifluoromethoxybenzene sulfonamide is obtained through ammoniation. According to the method, the oxidizing agent is added in the synthesis process and oxidizes sulfinic acid into sulfonyl chloride, so that the reaction yield is increased; the oxidizing agent reacts with excessive sulfur dioxide, so that the feeding amount of ammonia during ammoniation is reduced, the discharge of excessive ammonia gas is reduced, and the environment is protected; the whole process is simple to operate, low in cost and suitable for industrial production. 本发明公开了一种2-三氟甲氧基苯磺酰胺的制备方法，属于医药中间体技术领域。以邻氨基三氟甲氧基苯为起始原料，通过重氮化、氯磺化和氧化合成2-三氟甲氧基苯磺酰氯，接着氨化得到2-三氟甲氧基苯磺酰胺。本发明通过在合成过程中加入氧化剂，氧化剂将亚磺酸氧化为磺酰氯，提升反应收率；
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN117185967A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN117185967A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN117185967A3</originalsourceid><addsrcrecordid>eNrjZLAKKEotSCxKLMnMz1PITS3JyE9RyE9TMNItKcpMyynNL8oHC1ZUJqXmVaXmpRaX5qTl5yXmZqak8jCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxGSg-pJ4Zz9DQ3NDC1NLM3NHY2LUAADxRDBH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method of 2-trifluoromethoxybenzenesulfonamide</title><source>esp@cenet</source><creator>JIANG DIANBAO ; ZHOU XIN ; ZAN SHUJIN</creator><creatorcontrib>JIANG DIANBAO ; ZHOU XIN ; ZAN SHUJIN</creatorcontrib><description>The invention discloses a preparation method of 2-trifluoromethoxybenzenesulfonamide, and belongs to the technical field of medical intermediates. O-amino trifluoromethoxybenzene is used as a starting raw material, 2-trifluoromethoxybenzene sulfonyl chloride is synthesized through diazotization, chlorosulfonation and oxidation, and then the 2-trifluoromethoxybenzene sulfonamide is obtained through ammoniation. According to the method, the oxidizing agent is added in the synthesis process and oxidizes sulfinic acid into sulfonyl chloride, so that the reaction yield is increased; the oxidizing agent reacts with excessive sulfur dioxide, so that the feeding amount of ammonia during ammoniation is reduced, the discharge of excessive ammonia gas is reduced, and the environment is protected; the whole process is simple to operate, low in cost and suitable for industrial production. 本发明公开了一种2-三氟甲氧基苯磺酰胺的制备方法，属于医药中间体技术领域。以邻氨基三氟甲氧基苯为起始原料，通过重氮化、氯磺化和氧化合成2-三氟甲氧基苯磺酰氯，接着氨化得到2-三氟甲氧基苯磺酰胺。本发明通过在合成过程中加入氧化剂，氧化剂将亚磺酸氧化为磺酰氯，提升反应收率；</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20231208&amp;DB=EPODOC&amp;CC=CN&amp;NR=117185967A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20231208&amp;DB=EPODOC&amp;CC=CN&amp;NR=117185967A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIANG DIANBAO</creatorcontrib><creatorcontrib>ZHOU XIN</creatorcontrib><creatorcontrib>ZAN SHUJIN</creatorcontrib><title>Preparation method of 2-trifluoromethoxybenzenesulfonamide</title><description>The invention discloses a preparation method of 2-trifluoromethoxybenzenesulfonamide, and belongs to the technical field of medical intermediates. O-amino trifluoromethoxybenzene is used as a starting raw material, 2-trifluoromethoxybenzene sulfonyl chloride is synthesized through diazotization, chlorosulfonation and oxidation, and then the 2-trifluoromethoxybenzene sulfonamide is obtained through ammoniation. According to the method, the oxidizing agent is added in the synthesis process and oxidizes sulfinic acid into sulfonyl chloride, so that the reaction yield is increased; the oxidizing agent reacts with excessive sulfur dioxide, so that the feeding amount of ammonia during ammoniation is reduced, the discharge of excessive ammonia gas is reduced, and the environment is protected; the whole process is simple to operate, low in cost and suitable for industrial production. 本发明公开了一种2-三氟甲氧基苯磺酰胺的制备方法，属于医药中间体技术领域。以邻氨基三氟甲氧基苯为起始原料，通过重氮化、氯磺化和氧化合成2-三氟甲氧基苯磺酰氯，接着氨化得到2-三氟甲氧基苯磺酰胺。本发明通过在合成过程中加入氧化剂，氧化剂将亚磺酸氧化为磺酰氯，提升反应收率；</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAKKEotSCxKLMnMz1PITS3JyE9RyE9TMNItKcpMyynNL8oHC1ZUJqXmVaXmpRaX5qTl5yXmZqak8jCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxGSg-pJ4Zz9DQ3NDC1NLM3NHY2LUAADxRDBH</recordid><startdate>20231208</startdate><enddate>20231208</enddate><creator>JIANG DIANBAO</creator><creator>ZHOU XIN</creator><creator>ZAN SHUJIN</creator><scope>EVB</scope></search><sort><creationdate>20231208</creationdate><title>Preparation method of 2-trifluoromethoxybenzenesulfonamide</title><author>JIANG DIANBAO ; ZHOU XIN ; ZAN SHUJIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117185967A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>JIANG DIANBAO</creatorcontrib><creatorcontrib>ZHOU XIN</creatorcontrib><creatorcontrib>ZAN SHUJIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIANG DIANBAO</au><au>ZHOU XIN</au><au>ZAN SHUJIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of 2-trifluoromethoxybenzenesulfonamide</title><date>2023-12-08</date><risdate>2023</risdate><abstract>The invention discloses a preparation method of 2-trifluoromethoxybenzenesulfonamide, and belongs to the technical field of medical intermediates. O-amino trifluoromethoxybenzene is used as a starting raw material, 2-trifluoromethoxybenzene sulfonyl chloride is synthesized through diazotization, chlorosulfonation and oxidation, and then the 2-trifluoromethoxybenzene sulfonamide is obtained through ammoniation. According to the method, the oxidizing agent is added in the synthesis process and oxidizes sulfinic acid into sulfonyl chloride, so that the reaction yield is increased; the oxidizing agent reacts with excessive sulfur dioxide, so that the feeding amount of ammonia during ammoniation is reduced, the discharge of excessive ammonia gas is reduced, and the environment is protected; the whole process is simple to operate, low in cost and suitable for industrial production. 本发明公开了一种2-三氟甲氧基苯磺酰胺的制备方法，属于医药中间体技术领域。以邻氨基三氟甲氧基苯为起始原料，通过重氮化、氯磺化和氧化合成2-三氟甲氧基苯磺酰氯，接着氨化得到2-三氟甲氧基苯磺酰胺。本发明通过在合成过程中加入氧化剂，氧化剂将亚磺酸氧化为磺酰氯，提升反应收率；</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN117185967A
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Preparation method of 2-trifluoromethoxybenzenesulfonamide
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T19%3A42%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JIANG%20DIANBAO&rft.date=2023-12-08&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN117185967A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true