Preparation method of 2-trifluoromethoxybenzenesulfonamide

The invention discloses a preparation method of 2-trifluoromethoxybenzenesulfonamide, and belongs to the technical field of medical intermediates. O-amino trifluoromethoxybenzene is used as a starting raw material, 2-trifluoromethoxybenzene sulfonyl chloride is synthesized through diazotization, chlorosulfonation and oxidation, and then the 2-trifluoromethoxybenzene sulfonamide is obtained through ammoniation. According to the method, the oxidizing agent is added in the synthesis process and oxidizes sulfinic acid into sulfonyl chloride, so that the reaction yield is increased; the oxidizing agent reacts with excessive sulfur dioxide, so that the feeding amount of ammonia during ammoniation is reduced, the discharge of excessive ammonia gas is reduced, and the environment is protected; the whole process is simple to operate, low in cost and suitable for industrial production. 本发明公开了一种2-三氟甲氧基苯磺酰胺的制备方法，属于医药中间体技术领域。以邻氨基三氟甲氧基苯为起始原料，通过重氮化、氯磺化和氧化合成2-三氟甲氧基苯磺酰氯，接着氨化得到2-三氟甲氧基苯磺酰胺。本发明通过在合成过程中加入氧化剂，氧化剂将亚磺酸氧化为磺酰氯，提升反应收率；