Albumin coating with anticoagulation and/or in-situ endothelialization function as well as preparation method and application thereof

The invention relates to the technical field of medical materials, and discloses an albumin coating with anticoagulation and/or in-situ endothelialization functions as well as a preparation method and application thereof. The preparation method comprises the following steps: soaking an activated substrate in a siloxane solution containing an epoxy functional group to obtain a modified substrate; or standing the activated substrate and siloxane containing an epoxy functional group in a vacuum environment to obtain a modified substrate; and soaking the modified substrate in an albumin solution to obtain the albumin coating. The albumin coating not only has an excellent anticoagulation function, but also has an in-situ endothelialization function, can quickly form a complete endodermis on the surface of the coating, inhibits excessive proliferation of smooth muscle cells, avoids postoperative restenosis, and has a good application prospect. The material can be used on the surfaces of a series of implantable inte