MiR-99a-5p simulant and application thereof in preparation of medicine for preventing or treating hepatic fibrosis
The invention discloses a miR-99a-5p simulant and application thereof in preparation of a medicine for preventing or treating hepatic fibrosis, the nucleotide sequence of the miR-99a-5p simulant is shown as SEQ ID No: 1, the 3'end of the nucleotide sequence is subjected to methylation modificat...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | JIANG MENG HAN JIAYI ZHANG JUNYU LYU JIAYING JI JULING SUN YUFENG |
| description | The invention discloses a miR-99a-5p simulant and application thereof in preparation of a medicine for preventing or treating hepatic fibrosis, the nucleotide sequence of the miR-99a-5p simulant is shown as SEQ ID No: 1, the 3'end of the nucleotide sequence is subjected to methylation modification, and the 5 'end of the nucleotide sequence is subjected to cholesterol modification. The miR-99a-5p simulant disclosed by the invention can be used for remarkably improving the occurrence and development of the hepatic fibrosis model by directly acting on ECM (extracellular matrix), and can be used for clinically preventing or treating hepatic fibrosis. The medicine for inhibiting hepatic fibrosis provided by the invention is high in safety degree, relatively strong in pharmacological action and clear in curative effect. The invention provides a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching liver injury related diseases, is easy to popularize and apply clinically, an |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN117165587A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN117165587A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN117165587A3</originalsourceid><addsrcrecordid>eNqNizsOwkAMRNNQIOAO5gApIhRCShSBaKBA9MhsvMRS4l15DecnfA5ANTNvZqaZHvmc1zXmZYTEw6NHMUBpAWPs2aFxELCOlIIHFohKEfWLRzJQy46FwAd9d08SY7nDmEwJP74bH8YOPN80JE7zbOKxT7T46Sxb7neX5pBTDFdKER0J2bU5FUVVrMtyU21X_2xeddlDvA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>MiR-99a-5p simulant and application thereof in preparation of medicine for preventing or treating hepatic fibrosis</title><source>esp@cenet</source><creator>JIANG MENG ; HAN JIAYI ; ZHANG JUNYU ; LYU JIAYING ; JI JULING ; SUN YUFENG</creator><creatorcontrib>JIANG MENG ; HAN JIAYI ; ZHANG JUNYU ; LYU JIAYING ; JI JULING ; SUN YUFENG</creatorcontrib><description>The invention discloses a miR-99a-5p simulant and application thereof in preparation of a medicine for preventing or treating hepatic fibrosis, the nucleotide sequence of the miR-99a-5p simulant is shown as SEQ ID No: 1, the 3'end of the nucleotide sequence is subjected to methylation modification, and the 5 'end of the nucleotide sequence is subjected to cholesterol modification. The miR-99a-5p simulant disclosed by the invention can be used for remarkably improving the occurrence and development of the hepatic fibrosis model by directly acting on ECM (extracellular matrix), and can be used for clinically preventing or treating hepatic fibrosis. The medicine for inhibiting hepatic fibrosis provided by the invention is high in safety degree, relatively strong in pharmacological action and clear in curative effect. The invention provides a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching liver injury related diseases, is easy to popularize and apply clinically, an</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231205&DB=EPODOC&CC=CN&NR=117165587A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231205&DB=EPODOC&CC=CN&NR=117165587A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIANG MENG</creatorcontrib><creatorcontrib>HAN JIAYI</creatorcontrib><creatorcontrib>ZHANG JUNYU</creatorcontrib><creatorcontrib>LYU JIAYING</creatorcontrib><creatorcontrib>JI JULING</creatorcontrib><creatorcontrib>SUN YUFENG</creatorcontrib><title>MiR-99a-5p simulant and application thereof in preparation of medicine for preventing or treating hepatic fibrosis</title><description>The invention discloses a miR-99a-5p simulant and application thereof in preparation of a medicine for preventing or treating hepatic fibrosis, the nucleotide sequence of the miR-99a-5p simulant is shown as SEQ ID No: 1, the 3'end of the nucleotide sequence is subjected to methylation modification, and the 5 'end of the nucleotide sequence is subjected to cholesterol modification. The miR-99a-5p simulant disclosed by the invention can be used for remarkably improving the occurrence and development of the hepatic fibrosis model by directly acting on ECM (extracellular matrix), and can be used for clinically preventing or treating hepatic fibrosis. The medicine for inhibiting hepatic fibrosis provided by the invention is high in safety degree, relatively strong in pharmacological action and clear in curative effect. The invention provides a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching liver injury related diseases, is easy to popularize and apply clinically, an</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNizsOwkAMRNNQIOAO5gApIhRCShSBaKBA9MhsvMRS4l15DecnfA5ANTNvZqaZHvmc1zXmZYTEw6NHMUBpAWPs2aFxELCOlIIHFohKEfWLRzJQy46FwAd9d08SY7nDmEwJP74bH8YOPN80JE7zbOKxT7T46Sxb7neX5pBTDFdKER0J2bU5FUVVrMtyU21X_2xeddlDvA</recordid><startdate>20231205</startdate><enddate>20231205</enddate><creator>JIANG MENG</creator><creator>HAN JIAYI</creator><creator>ZHANG JUNYU</creator><creator>LYU JIAYING</creator><creator>JI JULING</creator><creator>SUN YUFENG</creator><scope>EVB</scope></search><sort><creationdate>20231205</creationdate><title>MiR-99a-5p simulant and application thereof in preparation of medicine for preventing or treating hepatic fibrosis</title><author>JIANG MENG ; HAN JIAYI ; ZHANG JUNYU ; LYU JIAYING ; JI JULING ; SUN YUFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN117165587A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>JIANG MENG</creatorcontrib><creatorcontrib>HAN JIAYI</creatorcontrib><creatorcontrib>ZHANG JUNYU</creatorcontrib><creatorcontrib>LYU JIAYING</creatorcontrib><creatorcontrib>JI JULING</creatorcontrib><creatorcontrib>SUN YUFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIANG MENG</au><au>HAN JIAYI</au><au>ZHANG JUNYU</au><au>LYU JIAYING</au><au>JI JULING</au><au>SUN YUFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MiR-99a-5p simulant and application thereof in preparation of medicine for preventing or treating hepatic fibrosis</title><date>2023-12-05</date><risdate>2023</risdate><abstract>The invention discloses a miR-99a-5p simulant and application thereof in preparation of a medicine for preventing or treating hepatic fibrosis, the nucleotide sequence of the miR-99a-5p simulant is shown as SEQ ID No: 1, the 3'end of the nucleotide sequence is subjected to methylation modification, and the 5 'end of the nucleotide sequence is subjected to cholesterol modification. The miR-99a-5p simulant disclosed by the invention can be used for remarkably improving the occurrence and development of the hepatic fibrosis model by directly acting on ECM (extracellular matrix), and can be used for clinically preventing or treating hepatic fibrosis. The medicine for inhibiting hepatic fibrosis provided by the invention is high in safety degree, relatively strong in pharmacological action and clear in curative effect. The invention provides a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching liver injury related diseases, is easy to popularize and apply clinically, an</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN117165587A |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | MiR-99a-5p simulant and application thereof in preparation of medicine for preventing or treating hepatic fibrosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T05%3A32%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JIANG%20MENG&rft.date=2023-12-05&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN117165587A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |