MiR-99a-5p simulant and application thereof in preparation of medicine for preventing or treating hepatic fibrosis

The invention discloses a miR-99a-5p simulant and application thereof in preparation of a medicine for preventing or treating hepatic fibrosis, the nucleotide sequence of the miR-99a-5p simulant is shown as SEQ ID No: 1, the 3'end of the nucleotide sequence is subjected to methylation modification, and the 5 'end of the nucleotide sequence is subjected to cholesterol modification. The miR-99a-5p simulant disclosed by the invention can be used for remarkably improving the occurrence and development of the hepatic fibrosis model by directly acting on ECM (extracellular matrix), and can be used for clinically preventing or treating hepatic fibrosis. The medicine for inhibiting hepatic fibrosis provided by the invention is high in safety degree, relatively strong in pharmacological action and clear in curative effect. The invention provides a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching liver injury related diseases, is easy to popularize and apply clinically, an