Photoresponse temperature-sensitive hydrogel capable of enhancing drug delivery and application of photoresponse temperature-sensitive hydrogel in psoriasis treatment

The invention discloses a photo-response temperature-sensitive hydrogel capable of enhancing drug delivery and application thereof in psoriasis treatment, and the photo-response temperature-sensitive hydrogel takes amphiphilic high-molecular polymer hydrogel as a carrier, and simultaneously loads an immunosuppressive agent and a photo-thermal conversion core gold nanorod which are administrated by a system. According to the present invention, the systematically administered immunosuppressant is adopted as the external preparation to treat psoriasis through percutaneous delivery under specific wave band light irradiation, such that the light controlled drug release and the effective percutaneous permeation can be achieved, the abnormal proliferation of keratinocytes can be significantly inhibited, the cutin exfoliation can be significantly promoted, and the percutaneous administration and the effective treatment of psoriasis can be achieved. 本发明公开了一种可增强药物递送的光响应温敏水凝胶及其在银屑病治疗中的应用，是以两亲性高分子聚合物水凝胶为载体，同时装载系统给药的免疫抑制剂