Pharmaceutical compounds as ubiquitin-specific protease 19 (USP19) inhibitors

Pharmaceutical compounds as ubiquitin-specific protease 19 (USP19) inhibitors

# imgabs0 #. The present invention relates to compounds of formula (I) useful as inhibitors of ubiquitin-specific protease USP19 activity. The invention also relates to pharmaceutical compositions comprising these compounds and methods of using these compounds in therapy. #imgabs0#本发明涉及可用作泛素特异性蛋白酶US...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WHITEHEAD STEVEN K, HARRISON TIMOTHY, HELM MATTHEW D, BURKAMP FRANK, O 'DOWD COLIN, ROUNTREE JAMES SAMUEL SHANE, SHEPHERD STEVEN D
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:# imgabs0 #. The present invention relates to compounds of formula (I) useful as inhibitors of ubiquitin-specific protease USP19 activity. The invention also relates to pharmaceutical compositions comprising these compounds and methods of using these compounds in therapy. #imgabs0#本发明涉及可用作泛素特异性蛋白酶USP19活性抑制剂的式(I)的化合物。本发明还涉及包含这些化合物的药物组合物以及将这些化合物用于治疗的方法。