Application of medicine in treatment of tumor diseases

The invention relates to an application of a medicine in treating tumor diseases. Specifically, the invention provides the application of the bioactive substance conjugate shown in the formula (I) in the treatment of tumor diseases, and the tumor diseases are particularly preferably used for treating local advanced or metastatic solid tumors which are difficult to treat and cannot be resected by surgery according to the existing standard. Comprise but are not limited to breast cancer, stomach cancer, lung cancer, ovarian cancer, urothelial cancer, esophageal cancer, liver cancer, colorectal cancer, cervical cancer, endometrial cancer, pancreatic cancer and brain tumor. 本发明涉及药物在治疗肿瘤疾病中的应用。具体地，本发明提供式(I)所示生物活性物偶联物在治疗肿瘤疾病中的应用，所述肿瘤疾病特别优选依照现有标准治疗难治的不可手术切除的局部晚期或转移性实体瘤，包括但不限于乳腺癌、胃癌、肺癌、卵巢癌、尿路上皮癌、食管癌、肝癌、结直肠癌、宫颈癌、子宫内膜癌、胰腺癌、和脑肿瘤。