Compounds, compositions and methods for modulating FGF activity

The present invention features compounds that modulate FGF activity, for example by enhancing the binding between FGF-2 and its receptor, such as FGF-R1. The invention also features pharmaceutical compositions containing one or more of the compounds, methods of treating an injury or disease (e.g., stroke, hypogonadotrophin congenital hypogonadism, and viral infections) using the pharmaceutical compositions, and methods of increasing spermatogenesis. 本发明的特征在于调节FGF活性的化合物，例如通过增强FGF-2与其受体例如FGF-R1之间的结合来调节FGF活性。本发明的特征还在于含有一种或多种所述化合物的药物组合物、使用所述药物组合物治疗损伤或疾病(例如，中风、先天性低促性腺激素性性腺功能减退症和病毒感染)的方法及增加精子发生的方法。