Preparation method and intermediate of drug connector conjugate

The invention provides a preparation method of a drug connector conjugate and an intermediate of the drug connector conjugate. The invention specifically provides a preparation method of a drug connector conjugate. The invention also provides a preparation method of the intermediate or the salt thereof and application of the intermediate or the salt thereof. The preparation method provided by the invention has the advantages of easily available raw materials, simple operation and high product purity, and is suitable for large-scale synthesis. 本发明提供了一种药物连接体偶联物的制备方法及其中间体。具体提供了一种药物连接体偶联物的制备方法。还提供了所用中间体或其盐的制备方法和中间体或其盐的用途。本发明所述制备方法涉及的原料易得，操作简单，产品纯度高，适合放量合成。