8-hydroxyquinoline-N-oxide zinc complex, preparation method and application

The invention discloses an 8-hydroxyquinoline-N-oxide zinc complex and a preparation method thereof, belongs to the technical field of medicines, and solves the technical problem of drug resistance in the use process of existing platinum drugs. The method specifically comprises the following steps: mixing active ligands, zinc chloride, methanol, triethylamine, dichloromethane and auxiliary ligands in a pressure-resistant tube; and after the reaction is finished, cooling to room temperature, so as to obtain the target complex. Research finds that the complex has a good inhibition effect on SK-OV-3/DDP, the IC50 value of the complex is 0.47-11.67 [mu] M and is far greater than that of a clinical drug cis-platinum, and the toxicity of the complex to normal HL-7702 cells is very small, so that the complex has selectivity to tumor cells, overcomes the drug resistance of clinical drugs, has potential medicinal value and is expected to be used for preparing various antitumor drugs. 本发明公开了一种8-羟基喹啉-N-氧化物锌配合物及其制备方法，属于医