Tumor permeation type carrier-free nano-drug as well as preparation method and application thereof

The invention discloses a tumor penetration type carrier-free nano-drug as well as a preparation method and application thereof, and belongs to the field of nano-drugs. The carrier-free nano-drug can significantly improve the water solubility of a water-insoluble compound, has mitochondrial targeting and tumor active infiltration capacity, and can be mostly transferred into mitochondria under the action of a tertiary amine nitrogen-oxygen group, thereby being beneficial to inducing mitochondrial membrane potential reduction and apoptosis; the carrier-free nano-drug also has good blood long-circulation effect and tumor accumulation capacity in vivo, the tumor inhibition effect is superior to that of clinical medication, and the carrier-free nano-drug also has good biological safety. The preparation method is simple and can be used for preparing antitumor drugs. 本发明公开了一种肿瘤渗透型无载体纳米药物及其制备方法与应用，属于纳米药物领域。本发明的无载体纳米药物能显著提高水难溶性化合物的水溶性，具有线粒体靶向性和肿瘤主动渗透能力，在三级胺氮氧基团的作用下无载体纳米药物能大部分被转运至线粒体中，有利于诱导线粒体膜电位下降，使细胞凋亡；无载体纳米药物在体内还具有良