Alga lactone compound with anti-tumor activity as well as preparation method and application thereof

The invention relates to an algal lactone compound as well as a preparation method and application thereof, and belongs to the field of marine natural products. The algal lactone compound is obtained by extraction and separation from sargassum thunbergii, an anti-tumor activity experiment shows that the median inhibitory concentration (IC50) of the compound to human kidney clear cell adenocarcinoma cells (786-O), human gallbladder cancer cells (GBC-SD) and human embryo kidney cells (293T) is 8.4 mu M, 4.6 mu M and 6.2 mu M, and meanwhile, the compound also has proliferation inhibition activity to human gastric cancer cells (MKN-45) and human cervical cancer cells (HeLa). The compound can be used for preparing anti-tumor drugs. 本发明涉及一种海藻内酯类化合物及其制备方法和应用，属于海洋天然产物领域。该海藻内酯类化合物从鼠尾藻中经提取、分离获得，经抗肿瘤活性实验得出化合物对人肾透明细胞腺癌细胞（786-O）、人胆囊癌细胞（GBC-SD）、人胚肾细胞（293T）的半数抑制浓度（IC50）为8.4、4.6、6.2μM，同时该化合物还对人胃癌细胞（MKN-45）和人宫颈癌细胞（HeLa）具有增殖抑制活性。可用于制备抗肿瘤的药物。