Alkylation reaction of aza-uracil under visible light catalysis

The invention provides a preparation method of 6-alkyl aza-uracil under visible light catalysis, which is characterized in that aza-uracil and an alkyl peroxide acyl compound are used as raw materials and 2, 4, 5, 6-tetra (9-carbazolyl)-isophthalonitrile 4CzIPN is used as a photocatalyst under the condition of room-temperature visible light irradiation, so that aza-uracil C-6 site alkylation is realized. The method has the advantages of use of a green solvent, avoidance of metal addition, easily available raw materials, simple operation, low experiment cost and the like. The method fills the vacancy of direct alkylation of 6-site C-H bonds of aza-uracil. According to the alkylation reaction of the method, post-modification of active molecules such as drug molecules diclazuril containing an azuracil skeleton can be realized, and part of synthesized compounds have certain antitumor activity. 本发明提出了可见光催化下6-烷基氮杂尿嘧啶的制备方法：在室温可见光照射的条件下使用氮杂尿嘧啶和烷基过氧化酰化合物作为原料，2,4,5,6-四(9-咔唑基)-间苯二腈4CzIPN为光催化剂，实现了氮杂尿嘧啶C-6位烷基化。该方法具有使用绿色溶剂