Methods and compositions for cell therapy

Provided herein is a synthetic complex comprising one or more human leukocyte antigens (synHLA), wherein the complex is inhibited from eliciting an immune response. Also provided are nucleic acid molecules encoding the complexes, non-immunocompetence stem cells comprising the complexes or the nucleic acid molecules, and methods of treating a disease or condition comprising administering the complexes, the nucleic acid molecules, or the non-immunocompetence stem cells to a subject in need thereof. 本文提供了一种包含一个或多个人白细胞抗原(synHLA)的合成复合物，其中所述复合物被抑制引发免疫应答。还提供了编码所述复合物的核酸分子、包含所述复合物或所述核酸分子的无免疫能力干细胞以及治疗疾病或病症的方法，所述方法包括向有需要的对象施用所述复合物、所述核酸分子或所述无免疫能力干细胞。