Novel indoleamine 2, 3-dioxygenase inhibitor, preparation method thereof and pharmaceutical composition containing same

The present invention provides a novel compound having a cyclohexyl-(alkyl or cycloalkyl substituted) ethylidene-amino-heteroaryl moiety (cyclohexyl-(alkyl or cycloalkyl-substituted) ethene-amine-hetero-aryl), or a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a ph...

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Bibliographische Detailangaben
Hauptverfasser: YOON HYUN-SIK, PARK SOL, LEE DONG HOON, KIM SOO-HWA, LEE KYU-JIN, LEE EUICHEOL, PARK JONGSEOK, KANG HO-WOONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention provides a novel compound having a cyclohexyl-(alkyl or cycloalkyl substituted) ethylidene-amino-heteroaryl moiety (cyclohexyl-(alkyl or cycloalkyl-substituted) ethene-amine-hetero-aryl), or a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The present invention also provides a pharmaceutical composition comprising the same, and a pharmaceutical composition comprising the same. According to the present invention, the compound or the pharmaceutically acceptable salt thereof not only has excellent inhibitory activity on indoleamine 2, 3-dioxygenase (IDO), but also has a significantly high in-vivo exposure after oral administration, such that the compound or the pharmaceutically acceptable salt thereof can be used in the preparation of drugs for treating indoleamine 2, 3-dioxygenase (IDO), and can be used in the preparation of drugs for treating indoleamine 2, 3-dioxygenase (IDO), such as i