Oral nanoparticle of bioactive substance and preparation method thereof

The invention relates to a nanoparticle for oral administration, a preparation method and application thereof. The nanoparticle for oral administration is used for oral administration of bioactive substances which are mainly administered through injection due to low bioavailability caused by the problems of solubility, digestive tract decomposition and intestinal permeability. Furthermore, the present invention relates to an oral nanoparticle having the effect of maintaining or protecting the balance of intestinal microbiota by minimizing the exposure of bioactive substances to the intestinal microbiota, a formulation and a use thereof. 本发明涉及一种口服用纳米颗粒、配制方法及其用途，所述口服用纳米颗粒用于口服给药因溶解度、消化道内分解、肠渗透率问题导致生物利用度低而主要通过注射给药的生物活性物质。此外，本发明涉及一种口服用纳米颗粒、配制及其用途，所述口服用纳米颗粒通过最小化生物活性物质相对于肠道微生物群的暴露而具有保持或保护肠内微生物群平衡的效果。